Christoph Wilhelmy

Contact:

Position:

  • Pharmacist
  • PhD Student

Field of research

  • Lipid based mRNA delivery systems for cancer immunotherapy and vaccines

Publications

  • Wilhelmy C, Uebbing L, Kolb B, Graewert MA, Nawroth T, Haas H, Langguth P. Direct structural investigation of pH responsiveness in mRNA lipid nanoparticles: Refining paradigms. J Control Release. 2025 May 20;384:113848. doi: 10.1016/j.jconrel.2025.113848
  • D. Bi, C. Wilhelmy, D. Unthan, I. S. Keil, B. Zhao, B. Kolb, R. I. Koning, M. A. Graewert, B. Wouters, R. Zwier, J. Bussmann, T. Hankemeier, M. Diken, H. Haas, P. Langguth, M. Barz, H. Zhang, On the Influence of Fabrication Methods and Materials for mRNA-LNP Production: From Size and Morphology to Internal Structure and mRNA Delivery Performance In Vitro and In Vivo. Adv. Healthcare Mater. 2024, 2401252. https://doi.org/10.1002/adhm.202401252
  • Graewert, M.A., Wilhelmy, C., Bacic, T. et al. Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering. Sci Rep 13, 15764 (2023). https://doi.org/10.1038/s41598-023-42274-z
  • Wilhelmy, C., Keil, I.S., Uebbing, L., Schroer, M.A., Franke, D., Nawroth, T., Barz, M., Sahin, U., Haas, H., Diken, M., et al. Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy. Pharmaceutics 2023, 15, 2068.
  • Blechar, J. A., Al-Gousous, J., Wilhelmy, C., Postina, A. M., Getto, M., & Langguth, P.; Toward Mechanistic Design of Surrogate Buffers for Dissolution Testing of pH-Dependent Drug Delivery Systems. Pharmaceutics 2020, 12(12), 1197.

Poster presentations

  • DPhG annual meeting 2022: Relationship between structure and cellular efficacy of pH-responsive lipid nanoparticles (LNPs) 
    • Winner of the Lesmüller-Posterpreis
  • DESY Photon Science user meeting 2023: Quantitative, size dependent characterization of mRNA nanoparticles by in line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering
  • CLINAM 2023: Polysarcosine-Fucntionalized mRNA lipid nanoparticles tailored for immunotherapy
  • DPhG annual meeting 2024: Impact of Manufacturing Methods and Materials on mRNA LNPs: Size, Structure and Delivery performance in vitro and in vivo

  • Applied Biophysics Forum in Drug Delivery 2025: Investigating the pH dependency of mRNA lipid nanoparticles: a structural approach

Teaching:

  • Practical training (Pharmaceutical Technology; sterile dosage forms) for students in the 7th term