Contact: l.uebbing@uni-mainz.de
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Position
PhD student, research assistant, teaching assistant (7th semester practical training)
Field of research
Lipid based mRNA delivery systems for cancer immunotherapy and vaccines. (lipoplexes, lipid nanoparticles LNP)
Publications
Journal Articles
Uebbing L., Ziller A., Siewert C., Schroer M., Blanchet C., Svergun D., Ramishetty S., Peer D., Sahin U., Haas H,. Langguth P. Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering. Langmuir 44(36):13331-13341 (2020)
Siewert, C.D., Haas, H., Cornet, V., Nogueira, S.S., Nawroth, T., Uebbing, L., Ziller, A., Al-Gousous, J., Radulescu, A., Schroer, M.A., Blanchet C.E., Svergun D.I., Radsak M.P., Sahin U., Langguth P. Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA. Cells 9(9), 2034 (2020)
Uebbing, L., Klumpp, L., Webster, G. K. & Löbenberg, R. Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models. Drug Design, Development and Therapy 11:1163–1174 . (2017)
Ebert R, Helmstädter M, Stierle S, Uebbing L, Proschak E. Gliflozine: Hemmstoffe des renalen Glucose-Transporters. PZ Prisma 22(4):201–212. (2015)
Wagner B, Helmstädter M, Stierle S, Uebbing L, Peknice M, Zündorf I, Dingermann T, Fürst R. Stop the bleeding: Idarucizumab als Dabigatran-Antidot vor der Zulassung. Pharmakon 3(5):332-334. (2015)
Other Publications
Trehalose-Dihydrat. Kommentar zum Ph. Eur. 9.0. 62. Lfg. 2019
Lactulose-Sirup. Kommentar zum Ph. Eur. 9.5. 59. Lfg. 2018
Additional Information
Video portrait by SelectScience:
EMBL facilities support development of RNA vaccines
https://www.embl.org/news/science/biontech-uni-mainz-embl-hamburg/
DESYs Röntgenquelle PETRA III weist mögliche Wege zu besseren RNA-Impfstoffen
https://www.desy.de/aktuelles/news_suche/index_ger.html?openDirectAnchor=1977&two_columns=0